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In this session, insights from applications of electrophysiology in the clinical context will be discussed. These will include genotype-phenotype correlations in rare inherited eye diseases (of increasing importance in the era of new therapies) and case-based examples of clinical diagnostic dilemmas wherein electrophysiological tests were instrumental in securing the diagnosis. The speakers are leading scientists and clinicians with decades of experience in the clinical and/or scientific application of visual electrophysiology. The symposium will be of particular interest to clinicians who wonder how electrophysiology might fit into the optimal clinical management of patients in 2025 and beyond. Co-organisers: Omar Mahroo and Anthony Robson 90 min: 5 talks (each 15 min including Q&A if time), Then 15 min discussion time Speaker 1: Anthony Robson: Teenage cavities Speaker 2: Magella Neveu: Signal failure down the line… Speaker 3: Dorothy Thompson: Paediatric electrophysiology Speaker 4: Gordon Plant: Visual electrophysiology in neurology Speaker 5: Omar Mahroo: Interactive Retinal Cases 15 min discussion